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*Correspondence: Desheng Zhou [email protected] Liu [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This approach aligns with emerging clinical consensus that for people with significant metabolic dysfunction, intermittent or low-dose continuation may be more realistic than permanent discontinuation

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